Researchers have demonstrated that PE decreases joint oedema, cell migration, cartilage degradation and bone erosion.
PE significantly reduced the levels of proinflammatory cytokines and prostaglandin E2 in the joint as well as the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1.
Our data indicate that PE inhibits c-Jun N-terminal kinase, p38 and signal transducer and activator of transcription-3. In addition, PE decreases nuclear factor κB translocation leading to the down-regulation of the arthritic process.
These results support the interest of natural diet components in the development of therapeutic products for arthritic conditions.
article sourceExtra virgin olive - therapeutic products for arthritis,