Research: Cardio-metabolic & immunological impacts of EVOO consumption in overweight & obese older adults

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Both aging and obesity are related to deregulated immune function, which may be responsible for increased risk of infection and also chronic non-infectious diseases. Dietary lipids have been shown to impact immune and inflammatory responses and cardio-metabolic risk factors.

No information on the impact of olive oil on immune responses of overweight and obese older adults is available. Objective We aimed to determine the effect of replacing oils used in a typical American diet with extra virgin olive oil for 3 months on immune responses and cardio-metabolic risk factors in overweight and obese older adults.

Methods: This was a randomized, single-blinded and placebo-controlled trial in 41 overweight or obese participants who consumed a typical American diet. Participants in the control (CON, group were provided with a mixture of corn, soybean oil and butter, and those in the olive oil group, with extra virgin olive oil, to replace substitutable oils in their diet.

At baseline and 3 months, we measured blood pressure, biochemical and immunological parameters using fasting blood, and delayed-type hypersensitivity (DTH) skin response.

Results: Compared to the CON group, the OO group showed decreased systolic blood pressure, a strong trend toward increased plasma HDL-C concentrations and increased anti-CD3/anti-CD28 -stimulated T cell proliferation. No differences were found in T cell phenotype, cytokine production, and DTH response between the two groups.

Conclusions: Our results indicate that substitution of oils used in a typical American diet with extra virgin olive oil in overweight and obese older adults may have cardio-metabolic and immunological health benefits.

This trial was registered at clinicaltrials.gov as NCT01903304.

Authors: Mitra Rozati, Junaidah Barnett, Dayong WuGarry, Handelman Edward, Saltzman Thomas, Wilson Lijun, Li Junpeng, Wang Ascensin, Marcos Jos, Ordovs Yu-Chi Lee Mohsen MeydaniSimin Meydani
Credits/Source: Nutrition & Metabolism 2015.

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